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Store: Chemical tools for research

Our will is to make innovative chemical tools available to the research community worldwide. We are very proud to have so far commercialized three types of innovative products: membrane tension probes, turn-on probes for bioimaging and a new light-activated lipid molecule under exclusive distributors (Spirochome and Avanti). These tools showcase the performance of the NCCR Chemical Biology.

 

Membrane tension probes

Fluorescent membrane tension probe (Flipper-TR ®
Flipper-TR ® (published under the name FliptR) is the first live cell fluorescent membrane tension probe developed for the field of mechanobiology. The fluorescence lifetime ofFlipper-TR ® is strongly dependent on the membrane tension, therefore through FLIM imaging it is possible to measure precisely the spatio-temporal distribution of tension in membranes. This chemical tool opens up a whole new field by giving access to real time membrane tension measurements in live cells and artificial membranes.

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Lipid metabolism

Mito-caged sphingosine
Mito-caged sphingosine is a new light-activated lipid molecule  synthesized as an inactive molecule that would only localize to mitochondria and which can be activated with a flash of light. In human cells, activated mito-caged sphingosine is converted to sphingosine 1 phosphate within the mitochondria, before being exported rapidly to another compartment. The new compound represents a useful tool for many researchers studying both metabolism and signaling as well as those seeking a better understanding of mitochondria biology.

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Probes for bioimaging

1. SiR actin kit 
SiR-actin is a fluoregenic, cell permeable and highly specific probe for F-actin. Sir-actin is based on the F-actin binding natural product jasplakinolide. Sir-actin stains endogenous F-actin without the need for genetic manipulation or overexpression. Its emission in the far red minimizes phototoxicity and sample autofluorescence. SiR-actin is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets. SiR-actin can be used for widefield, confocal, SIM or STED imaging in living cells and tissue.

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2. SiR-tubulin kit
SiR-tubulin is a fluorogenic, cell permeable and highly specific probe for microtubules. SiR-tubulin is based on the microtubule binding drug Docetaxel. SiR-tubulin is fluorogenic, cell permeable and highly specific for microtubules. Sir-tubulin stains endogenous microtubules without the need for genetic manipulation or overexpression. Its emission in the far red minimizes phototoxicity and sample autofluorescence. SiR-tubulin is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets. SiR-tubulin can be used for widefield, confocal, SIM or STED imaging in living cells and tissue.

Description and details
References