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Commercialization of our research products showcases our performance and underline our will to make our innovative tools available to the research community world-wide through exclusive distributors.  The first-series of launched products includes turn-on probes for bio-imaging then a new light-activated lipid molecule followed. A third series is soon to be released.

 

Lipid metabolism

Mito-caged sphingosine
Mito-caged sphingosine is a new light-activated lipid molecule  synthesized as an inactive molecule that would only localize to mitochondria and which can be activated with a flash of light. In human cells, activated mito-caged sphingosine is converted to sphingosine 1 phosphate within the mitochondria, before being exported rapidly to another compartment. The new compound represents a useful tool for many researchers studying both metabolism and signaling as well as those seeking a better understanding of mitochondria biology.

Description and details
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Membrane tension probes

Fluorescent membrane tension probe (FliptR) 
FliptR is a membrane push-pull probe developed  for measuring tension probe (FliptR: “fluorescent lipid tension reporter”) which consists of two large dithienothiophene flippers. In a non-confining environment, the two flippers are twisted out of conjugation.  FliptR insert in an oriented fashion into membranes. It  has high photostability, partitions almost equally into different membrane phases, has different fluorescence absorption/emission spectra between lipid phase, does not change position following a lipid phase transition, and does not disturb membrane order. FliptR can planarize with an increase in lateral pressure.  It can be used to image a combination of lipid composition and membrane tension in live cells and artificial membranes.

Coming soon

 

Probes for bioimaging

1. SiR actin kit 
SiR-actin is a fluoregenic, cell permeable and highly specific probe for F-actin. Sir-actin is based on the F-actin binding natural product jasplakinolide. Sir-actin stains endogenous F-actin without the need for genetic manipulation or overexpression. Its emission in the far red minimizes phototoxicity and sample autofluorescence. SiR-actin is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets. SiR-actin can be used for widefield, confocal, SIM or STED imaging in living cells and tissue.
Description and details
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2. SiR-tubulin kit
SiR-tubulin is a fluorogenic, cell permeable and highly specific probe for microtubules. SiR-tubulin is based on the microtubule binding drug Docetaxel. SiR-tubulin is fluorogenic, cell permeable and highly specific for microtubules. Sir-tubulin stains endogenous microtubules without the need for genetic manipulation or overexpression. Its emission in the far red minimizes phototoxicity and sample autofluorescence. SiR-tubulin is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets. SiR-tubulin can be used for widefield, confocal, SIM or STED imaging in living cells and tissue.
Description and details
References