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The NCCR Chemical Biology develops turn-on probes for bio-imaging and provides them to the academic community through exclusive distributors.

 

Probes for bioimaging

1. SiR actin kit 
SiR-actin is a fluoregenic, cell permeable and highly specific probe for F-actin. Sir-actin is based on the F-actin binding natural product jasplakinolide. Sir-actin stains endogenous F-actin without the need for genetic manipulation or overexpression. Its emission in the far red minimizes phototoxicity and sample autofluorescence. SiR-actin is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets. SiR-actin can be used for widefield, confocal, SIM or STED imaging in living cells and tissue.
Description and details
References

 

2. SiR-tubulin kit
SiR-tubulin is a fluorogenic, cell permeable and highly specific probe for microtubules. SiR-tubulin is based on the microtubule binding drug Docetaxel. SiR-tubulin is fluorogenic, cell permeable and highly specific for microtubules. Sir-tubulin stains endogenous microtubules without the need for genetic manipulation or overexpression. Its emission in the far red minimizes phototoxicity and sample autofluorescence. SiR-tubulin is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets. SiR-tubulin can be used for widefield, confocal, SIM or STED imaging in living cells and tissue.
Description and details
References