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ACCESS – Chemical screening facility

Chemical screening
Copyright: Shem Johnson

The ACCESS screening facility was established within the framework of the NCCR Chemical Biology in 2010 to provide initially chemical diversity screening facilities and know-how in chemical genetics to academia in Switzerland.  Within that frame, ACCESS (which stands for “Academic Chemical Screens in Switzerland”) was first implemented  within the premises of the already running Biomolecular Screening Facility (BSF) at the EPFL. Today, a second antenna located in Geneva offers support to conduct image-based high-content screening (HCS) and high-throughput screening (HTS).

In Lausanne, BSF-ACCESS performs chemical screens with long-term expertise in chemical diversity, screening facilities and know-how in chemical genetics. From in vitro cellular target-based assays to complex phenotypic screens, chemical screens are available using a collection of more than 100’000 chemical compounds. This highly diverse chemical library from various commercial sources – including several specific libraries – is today available at BSF-ACCESS to provide a good coverage of the chemical 3D-structural space for drug–like molecules, including admitted drugs as well as natural compounds. In addition, the platform handles the Swiss Chemical Collection (SCC) comprising unique chemical compounds obtained from various Swiss chemistry laboratories, giving the community access to compounds that cannot be found elsewhere. A web portal shared by the users of BSF-ACCESS under a data sharing agreement allows for complex data analysis and further annotation of compounds.

In 2015, an antenna was established at the Department of Biochemistry of the University of Geneva. ACCESS Geneva complements and diversifies the screening services offered to the researchers in the Lémanic Area. The platform provides support to conduct image-based high-content screening (HCS) and high-throughput screening (HTS) within a complete infrastructure of automated station where most cell biology experimentation in large scale are handled, along with a very robust consistency and accuracy in a P2 environment. Image-based screening projects benefit from a solid expertise on image-based screening, data analysis and/or automated microscopy, based on a long experience in systems biology and high-throughput screening technology.

Training courses are regularly organized at both sites EPFL and UNIGE.

 

More info about the ACCESS screening facilities