Expanding small molecule diversity space beyond the commercial available space and providing the required synthetic chemistry expertise to follow up on identified hits.
Screening for small molecules that target various signaling and/or biosynthetic pathways in yeast and in higher eukaryotes.
Using protein engineering to generate new tools for studying biological questions.
Studying the cell as a physical object, which is subject to forces, pressures and tensions, using chemical sensors and biophysical tools.
Developing conceptually innovative approaches to cross membrane barriers and enter cells, and to image biologically important properties of biomembranes that are otherwise difficult to detect.
Running as many screens as possible with ACCESS, our platform for Academic Chemical Screens in Switzerland.