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Yimon Aye

Yimon Aye

Laboratory of Electrophile Signaling And Genome Operation, EPFL

About Yimon Aye

Yimon Aye was born and raised in Burma. She moved to the UK to study for sixth form (high school) and then read chemistry at Oxford University, UK. She moved to Harvard University, USA, achieving a PhD in organic chemistry under the supervision of Prof. David A. Evans. She then moved to Massachusetts Institute of Technology (USA) to research the cellular and biochemical regulatory mechanisms of the enzyme ribonucleotide reductase with Prof. JoAnne Stubbe. In her independent career at Cornell University that began in mid-2012, she set out to understand the detailed mechanisms of electrophile signaling. This impetus culminated in the development of “REX” technologies (T-REX™ delivery and G-REX™ profiling). In a parallel research program distinct from redox-dependent cell signaling, she studies proteins/pathways involved in mammalian genome maintenance and nucleotide signaling, including the mechanisms of anticancer agents in clinical use. As of August 2018, she is leading the Laboratory of Electrophile Signaling And Genome Operation (LEAGO) at ISIC, EPFL (Switzerland) as a tenured associate professor.

Yimon Aye joined the NCCR Chemical Biology in 2018 as a principal investigator. She is member of the NCCR steering committee.

Read more about Yimon Aye’s research on her lab website.



Ecole polytechnique fédérale de Lausanne
CH A2 397
Station 6
CH-1015 Lausanne


Marcus Long, Dziyana Hnedzko, Bo Kyoung Kim, Yimon Aye, “Breaking the fourth wall: Modulating quaternary associations for protein regulation and drug discovery”, ChemBioChem, 10.1002/cbic.201800716, 2019. [More Information]