About Yimon Aye
Yimon Aye was born and raised in Burma. She moved to the UK to study for sixth form (high
school) and then read chemistry at Oxford University, UK. She moved to Harvard
University, USA, achieving a PhD in organic chemistry under the supervision of Prof.
David A. Evans. She then moved to Massachusetts Institute of Technology (USA) to
research the cellular and biochemical regulatory mechanisms of the enzyme ribonucleotide
reductase with Prof. JoAnne Stubbe. In her independent career at Cornell University that
began in mid-2012, she set out to understand the detailed mechanisms of electrophile
signaling. This impetus culminated in the development of “REX” technologies
(T-REX™ delivery and G-REX™ profiling). In a parallel research program
distinct from redox-dependent cell signaling, she studies proteins/pathways involved in
mammalian genome maintenance and nucleotide signaling, including the mechanisms of
anticancer agents in clinical use. As of August 2018, she is leading the Laboratory of
Electrophile Signaling And Genome Operation (LEAGO) at ISIC, EPFL (Switzerland) as a
tenured associate professor.
Yimon Aye joined the NCCR Chemical Biology in 2018 as a principal investigator. She is
member of the NCCR steering
committee.
Read more about Yimon Aye’s research on her lab website.
Contact
Ecole polytechnique fédérale de Lausanne
EPFL SB ISIC LEAGO
CH A2 397
Station 6
CH-1015 Lausanne
Email: [email protected]
Publications
Poganik, J.R., Huang, KT., Parvez, S. et al. “Wdr1 and cofilin are
necessary mediators of immune-cell-specific apoptosis triggered by
Tecfidera”, Nat Commun 12, 5736 (2021).
Open access Dataset info
[More Information]
Marcus J C Long, Pierre A Miranda Herrera, Yimon Aye, “Hitting the
Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling
Regulation”, Chem Res Toxicol, 2022. Open
access [More
Information]
Marcus J. C. Long, Mahdi Assari, Yimon Aye, “Hiding in Plain Sight:
The Issue of Hidden Variables”, ACS
Chem. Biol., 17, 6 [More Information]
Yi Zhao, Pierre A. Miranda Herrera, Dalu Chang, Romain Hamelin, Marcus J.
C. Long, Yimon Aye, “Function-guided proximity mapping unveils
electrophilic-metabolite sensing by proteins not present in their
canonical locales”, PNAS, 2022. Open access Dataset info
[More Information]
Y. Aye, “Bringing Functional Context to Emerging
Proximity-mapping Proteomics Tools”, Chimia 2022,
76, 598. Open access
[More Information]
Long M., Ly P., Aye
Y. A, “Primer on Harnessing Non-enzymatic
Posttranslational Modifications for Drug Design”,
Preprints 2021, 2021050036. Open
access
[More Information]
Marcus J.C. Long, Yimon Aye, “Keap 1: The new Janus word on the
block”, Bioorganic & Medicinal Chemistry Letters, Volume
71, 2022. Open
access [More Information]
Long M.J.C., Huang K.T., Aye Y., “The not so identical twins:
(dis)similarities between reactive electrophile and oxidant sensing and
signaling”, Chem. Soc. Rev., 2021. Advance Article
[More Information]
Marcus J. C. Long, Amogh Kulkarni, Yimon Aye, “Can Precision
Electrophile Signaling Make a Meaningful and Lasting Impression in Drug
Design?”, Chembiochem, 2021. Free
access [More Information]
Marcus J. C. Long, Chloé Rogg, Yimon Aye, “An Oculus to Profile and
Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution
into G-REX”, Acc. Chem.
Res., 54, 3 [More Information]
Yimon Aye, “Where Electrophile Signaling and Covalent Ligand-Target
Mining Converge”, CHIMIA International Journal for
Chemistry, Volume 74, Number 9, pp. 659-666(8), 2020. Open
access [More
Information]
Marcus J.C. Long, Daniel A. Urul, Yimon Aye, “REX Technologies for
Profiling and Decoding the Electrophile Signaling Axes Mediated by
Rosetta Stone Proteins”, Methods Enzymol., 633:203-230,
2020. Contribution to a book: “Chemical and Synthetic Biology
Approaches To Understand Cellular Functions - Part C”, Edited by
Arun K. Shukla. [More Information]
Marcus Long, Lingxi Wang, Yimon Aye, “Getting the Right Grip? How
Understanding Electrophile Selectivity Profiles Could Illuminate Our
Understanding of Redox Signaling”, Antioxid Redox Signal,
doi: 10.1089/ars.2019.7894, 2019. [More Information]
Marcus J. C. Long, Yi Zhao, Yimon Aye, “Neighborhood watch: tools
for defining locale-dependent subproteomes and their contextual
signaling activities”, RSC Chemical Biology, 2020. Review
article. Open
access [More Information]
Jesse R. Poganik, Alexandra K. Van Hall‐Beauvais, Marcus J. C. Long,
Michael T. Disare, Yi Zhao, Yimon Aye, “The mRNA‐Binding Protein
HuR Is a Kinetically‐Privileged Electrophile Sensor”, Swiss
Helvetica, 2020. [More Information]
Xuyu Liu, Marcus J. C. Long, Benjamin D. Hopkins, Chaosheng Luo, Lingxi
Wang, and Yimon Aye, “Precision Targeting of pten-Null
Triple-Negative Breast Tumors Guided by Electrophilic Metabolite
Sensing”, ACS Central Science, 2020. Open
access [More Information]
Sascha Hoogendoorn and Yimon Aye, “Empowering Global
Chemical Biology at the Dawn of the New Decade”, ACS Chem. Biol., 2020. Proceedings of the International
Symposium on Chemical Biology, 22-24 January, 2020, Geneva,
Switzerland. [More Information]
Long M.J.C., Zhao Y., Aye Y., “Clofarabine Commandeers the
RNR-α-ZRANB3 Nuclear Signaling Axis”, Cell Chem Biol. Jan
16;27(1):122-133.e5, 2020. [More Information]
Poganik J.R., Long M.J.C., Disare M.T., Liu X., Chang S.H., Hla T., Aye
Y., “Post-transcriptional regulation of Nrf2-mRNA by the
mRNA-binding proteins HuR and AUF1”, FASEB J.,
33(12):14636-14652, 2019. Dataset info:
“Role of the mRNA-binding protein HuR in
the global transcriptomic status of cells stimulated with
electrophiles and oxidants“ [More
Information]
Long M., Van Hall-Beauvais A., Aye Y. “The more the merrier: how
homo-oligomerization alters the interactome and function of
ribonucleotide reductase”, Curr Opin Chem Biol. 2019 Nov
14;54:10-18. Review article. Paper will be freely available on pubmed
after 1 year embargo period. [More Information]
Jesse Poganik and Yimon Aye, “Electrophile Signaling and Emerging
Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals”,
Frontiers in Aging Neuroscience 12:1, 2020. Open
access [More Information]
Yimon Aye, Paul JHergenrother, “From the iceman to modern
medicine”, Current Opinion in Chemical Biology 2019, 50:A1–A2.
Open access
[More Information]
Hem Raj Khatri, Bijay Bhattarai, Will Kaplan, Zhongzheng Li, Marcus John
Curtis Long, Yimon Aye, and Pavel Nagorny, “Modular Total
Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin
and Other Cardiotonic Steroids with Varying Degrees of
Oxygenation”, J Am Chem Soc. 2019 Mar 27; 141(12): 4849–4860.
Open
access [More Information]
Yimon Aye, Kate S. Carroll, “Redox Pathways in Chemical
Toxicology”, Chem. Res. Toxicol.2019, 32, 3, [More Information]
Jesse R.
Poganik, Marcus J.C.
Long, Yimon Aye, “Interrogating Precision
Electrophile Signaling”, Trends in Biochemical Sciences,
Volume 44, Issue 4, April 2019, Pages 380-381. Free access from April
2020
[More Information]
Long M.J., Liu X., Aye Y., “Genie in a bottle: controlled release
helps tame natural polypharmacology?”, Curr
Opin Chem Biol. 2019 Aug;51:48-56. Free
access from August 2020 [More
Information]
Marcus Long, Dziyana Hnedzko, Bo Kyoung Kim, Yimon Aye, “Breaking
the fourth wall: Modulating quaternary associations for protein
regulation and drug discovery”, ChemBioChem,
10.1002/cbic.201800716, 2019. Free access from May
2020 [More Information]
Marcus J. C. Long, Xuyu Liu, Yimon Aye, “Chemical biology gateways
to mapping location, association, and pathway responsivity”,
Front. Chem., 21 March 2019. Open
access [More Information]
