About Yimon Aye
Yimon Aye was born and raised in Burma. She moved to the UK to study for sixth form (high school) and then read chemistry at Oxford University, UK. She moved to Harvard University, USA, achieving a PhD in organic chemistry under the supervision of Prof. David A. Evans. She then moved to Massachusetts Institute of Technology (USA) to research the cellular and biochemical regulatory mechanisms of the enzyme ribonucleotide reductase with Prof. JoAnne Stubbe. In her independent career at Cornell University that began in mid-2012, she set out to understand the detailed mechanisms of electrophile signaling. This impetus culminated in the development of “REX” technologies (T-REX™ delivery and G-REX™ profiling). In a parallel research program distinct from redox-dependent cell signaling, she studies proteins/pathways involved in mammalian genome maintenance and nucleotide signaling, including the mechanisms of anticancer agents in clinical use. As of August 2018, she is leading the Laboratory of Electrophile Signaling And Genome Operation (LEAGO) at ISIC, EPFL (Switzerland) as a tenured associate professor.
Yimon Aye joined the NCCR Chemical Biology in 2018 as a principal investigator. She is member of the NCCR steering committee.
Read more about Yimon Aye’s research on her lab website.
Ecole polytechnique fédérale de Lausanne
EPFL SB ISIC LEAGO
CH A2 397
Marcus J.C. Long, Daniel A. Urul, Yimon Aye, “REX Technologies for Profiling and Decoding the Electrophile Signaling Axes Mediated by Rosetta Stone Proteins”, Methods Enzymol., 633:203-230, 2020. Contribution to a book: “Chemical and Synthetic Biology Approaches To Understand Cellular Functions – Part C”, Edited by Arun K. Shukla. [More Information]
Marcus Long, Lingxi Wang, Yimon Aye, “Getting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox Signaling”, Antioxid Redox Signal, doi: 10.1089/ars.2019.7894, 2019. [More Information]
Marcus J. C. Long, Yi Zhao, Yimon Aye, “Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities”, RSC Chemical Biology, 2020. Review article. Open access [More Information]
Jesse R. Poganik, Alexandra K. Van Hall‐Beauvais, Marcus J. C. Long, Michael T. Disare, Yi Zhao, Yimon Aye, “The mRNA‐Binding Protein HuR Is a Kinetically‐Privileged Electrophile Sensor”, Swiss Helvetica, 2020. [More Information]
Xuyu Liu, Marcus J. C. Long, Benjamin D. Hopkins, Chaosheng Luo, Lingxi Wang, and Yimon Aye, “Precision Targeting of pten-Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing”, ACS Central Science, 2020. Open access [More Information]
Sascha Hoogendoorn and Yimon Aye, “Empowering Global Chemical Biology at the Dawn of the New Decade”, ACS Chem. Biol., 2020. Proceedings of the International Symposium on Chemical Biology, 22-24 January, 2020, Geneva, Switzerland. [More Information]
Long M.J.C., Zhao Y., Aye Y., “Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis”, Cell Chem Biol. Jan 16;27(1):122-133.e5, 2020. [More Information]
Poganik J.R., Long M.J.C., Disare M.T., Liu X., Chang S.H., Hla T., Aye Y., “Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1”, FASEB J., 33(12):14636-14652, 2019. Dataset info: “Role of the mRNA-binding protein HuR in the global transcriptomic status of cells stimulated with electrophiles and oxidants“ [More Information]
Long M., Van Hall-Beauvais A., Aye Y. “The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase”, Curr Opin Chem Biol. 2019 Nov 14;54:10-18. Review article. Paper will be freely available on pubmed after 1 year embargo period. [More Information]
Jesse Poganik and Yimon Aye, “Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals”, Frontiers in Aging Neuroscience 12:1, 2020. Open access [More Information]
Yimon Aye, Paul JHergenrother, “From the iceman to modern medicine”, Current Opinion in Chemical Biology 2019, 50:A1–A2. Open access [More Information]
Hem Raj Khatri, Bijay Bhattarai, Will Kaplan, Zhongzheng Li, Marcus John Curtis Long, Yimon Aye, and Pavel Nagorny, “Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation”, J Am Chem Soc. 2019 Mar 27; 141(12): 4849–4860. Open access [More Information]
Yimon Aye, Kate S. Carroll, “Redox Pathways in Chemical Toxicology”, Chem. Res. Toxicol.2019, 32, 3, [More Information]
Jesse R. Poganik, Marcus J.C. Long, Yimon Aye, “Interrogating Precision Electrophile Signaling”, Trends in Biochemical Sciences, Volume 44, Issue 4, April 2019, Pages 380-381. Free access from April 2020
Long M.J., Liu X., Aye Y., “Genie in a bottle: controlled release helps tame natural polypharmacology?”, Curr Opin Chem Biol. 2019 Aug;51:48-56. Free access from August 2020 [More Information]
Marcus Long, Dziyana Hnedzko, Bo Kyoung Kim, Yimon Aye, “Breaking the fourth wall: Modulating quaternary associations for protein regulation and drug discovery”, ChemBioChem, 10.1002/cbic.201800716, 2019. Free access from May 2020 [More Information]
Marcus J. C. Long, Xuyu Liu, Yimon Aye, “Chemical biology gateways to mapping location, association, and pathway responsivity”, Front. Chem., 21 March 2019. Open access [More Information]