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Sascha Hoogendoorn

Sascha Hoogendoorn

Department of Organic Chemistry, UNIGE

About Sascha Hoogendoorn

Sascha Hoogendoorn is a newly appointed tenure-track assistant professor in the department of Organic Chemistry and the NCCR Chemical Biology at the University of Geneva.  She received her PhD in Organic Chemistry from the group of professor Herman Overkleeft at the University of Leiden, the Netherlands in 2013. In her PhD work, she used synthetic chemistry to develop receptor-targeting small molecules to accomplish selective cellular entry. She then moved to Stanford University where she worked in the group of Professor James Chen as a postdoctoral scholar, and developed a novel CRISPR/Cas9-based screening methodology to study ciliary Hedgehog signalling.

In her lab she uses an interdisciplinary approach to study and perturb cellular signalling, with a particular interest in the primary cilium and the Hedgehog signalling pathway. Her research combines organic chemistry with cell biology and CRISPR/Cas9-based gene editing to develop molecules that enable further dissection and manipulation of ciliary signalling.

Sascha Hoogendoorn is a member of the educational committee for the Master’s in Chemical Biology.

Read more about Sascha Hoogendoorn’s research on her lab website or follow her on Twitter.



University of Geneva
Department of Organic Chemistry
30, Quai Ernest-Ansermet
1211, Geneva 4, Switzerland
Phone : +41 (0)22 379 60 85


Javier López-Andarias, Krikor Eblighatian, Quentin T. L. Pasquer, Lea Assies, Naomi Sakai, Sascha Hoogendoorn, Stefan Matile, “Photocleavable Fluorescent Membrane Tension Probes: Fast Release with Spatiotemporal Control in Inner Leaflets of Plasma Membrane, Nuclear Envelope, and Secretory Pathway”, Angew. Chem. Int. Ed. 2022, 61, e202113163. Open access Dataset info
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Assies Lea, García-Calvo José, Piazzolla Francesca, Sanchez Samantha, Kato Takehiro, Reymond Luc, Goujon Antoine, Colom Adai, López-Andarias Javier, Straková Karolína, Mahecic Dora, Mercier Vincent, Riggi Margot, Jiménez-Rojo Noemi, Roffay Chloé, Licari Giuseppe, Tsemperouli Maria, Neuhaus Frederik, Fürstenberg Alexandre, Vauthey Eric, Hoogendoorn Sascha, Gonzalez-Gaitan Marcos, Zumbuehl Andreas, Sugihara Kaori, Gruenberg Jean, Riezman Howard, Loewith Robbie, Manley Suliana, Roux Aurelien, Winssinger Nicolas, Sakai Naomi, Pitsch Stefan, Matile Stefan, “Flipper probes for the community”, CHIMIA International Journal for Chemistry, Volume 75, Number 12, 2021. Open access [More Information]

Quentin T. L. Pasquer, Ioannis A. Tsakoumagkos, Sascha Hoogendoorn, “From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological Systems”, Molecules25(23), 5702, 2020. Open access [More Information]

Sascha Hoogendoorn, “Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding”,  CHIMIA International Journal for Chemistry, 74, 9, 652-658(7), 2020. Open access [More Information]

Sascha Hoogendoorn and Yimon Aye, “Empowering Global Chemical Biology at the Dawn of the New Decade”, ACS Chem. Biol., 2020. Proceedings of the International Symposium on Chemical Biology, 22-24 January, 2020, Geneva, Switzerland. [More Information]