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Robbie Loewith

Robbie Loewith

Department of Molecular Biology, University of Geneva

About Robbie Loewith

Robbie Loewith received his bachelor in Biochemistry and Molecular Biology/Genetics in 1994 from the University of Guelph (Ontario, Canada). His PhD thesis – describing a novel tumor suppressor – was conducted at the Cancer Institute of Southern Alberta, in Dallan Young ‘s lab. He was granted his PhD degree in 2000 from the University of Calgary (Alberta, Canada). In 2005, following post-doctoral studies on the control of cell growth and in the laboratory of Michael Hall at the Biozentrum, University of Basle, Robbie Loewith joined the department of Molecular Biology of the University of Geneva as a project leader. In 2006, he was awarded an SNSF professorship, in 2008 an ERC Starting grant and in 2014 an ERC Consolidator grant. Since 2010, he has been part of the NCCR Chemical Biology as a project leader. He is Head of the educational committee for the Master’s in Chemical Biology and member of the NCCR steering committee. Today, Robbie Loewith is Full Professor in the Department of Molecular Biology.

With particular focus on the Target Of Rapamycin kinases, his group uses chemical genetic approaches in yeast to dissect complex signalling pathways conserved in all eukaryotes.

Read more about Robbie Loewith’s research on his lab website.

Contact

University of Geneva
Department of Molecular Biology
30, quai Ernest-Ansermet
CH-1211, Geneva 4, Switzerland
Phone: +41 (0)22 37 96116
Email: Robbie.Loewith@unige.ch

Publications

Plank M., Perepelkina M., Müller M., Vaga S., Zou X., Bourgoint C., Berti M., Saarbach J., Haesendonckx S., Winssinger N., Aebersold R., Loewith R., “Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9”, Mol. Cell Proteomics. 2020 Apr;19(4):655-671. Open access. Dataset info – Data set title: “Yeast AGC-kinases phospho-proteomics”. Responsible person: Robbie Loewith. [More Information]

Collado J, Kalemanov M, Campelo F, Bourgoint C, Thomas F, Loewith R, Martínez-Sánchez A, Baumeister W, Stefan CJ, Fernández-Busnadiego R., “Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity”, Dev Cell. 2019 Nov 18;51(4):476-487.e7.  Open access [More Information]

Margot Riggi, Beata Kusmider, Robbie Loewith, “The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance”, Journal of Cell Science, 133: jcs242040 doi: 10.1242/jcs.242040, 2020. [More Information]

Serbyn N., Noireterre A., Bagdiul I., Plank M., Michel A.H., Loewith R., Kornmann B., Stutz F., “The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast”, Mol Cell. 2019 Dec 23. pii: S1097-2765(19)30898-6. [More Information]

Karuppasamy M., Kusmider B., Oliveira T.M., Gaubitz C., Prouteau M., Loewith R. & Schaffitzel C., “Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2”, Nat. Commun. 8, Article number: 1729, 2017. [Link]

Manoël Prouteau, Ambroise Desfosses, Christian Sieben, Clélia Bourgoint, Nour Lydia Mozaffari, Davide Demurtas, Alok K. Mitra, Paul Guichard, Suliana Manley, Robbie Loewith, “TORC1 Organised in Inhibited Domains (TOROIDs) regulate TORC1 activity”, Nature, 2017. [More Information]

Shekhar-Guturja T., Gunaherath G.M.K.B., Wijeratne E.M.K., Lambert J.-P., Averette A.F., Lee S.C., Kim T, Bahn Y.-S., Tripodi F., Ammar R., Döhl K., Niewola-Staszkowska K., Schmitt L, Loewith R.J., Roth F.P., Sanglard D., Andes D., Nislow C., Coccetti P., Gingras A.-C., Heitman J., Gunatilaka A.A.L. and Cowen L.E.  “Dual Action Small Molecule Potentiates Antifungal Efficacy, Blocks the Evolution of Drug Resistance, and Renders Resistant Pathogens Responsive to Therapy via Modulation of Multidrug Efflux and TOR Signaling”. Nat. Chem Biol, in press (2016).

Kennedy M.A., Moffat T.C., Gable K., Ganesan S., Niewola-Staszkowska K., Johnston A., Nislow C., Giaever G., Harris L.J., Loewith R., Zaremberg V., Harper M.E., Dunn T., Bennett S.A., Baetz K., “A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction”, Sci. Rep. (2016 Jan) 13;6:19332. doi: 10.1038/ srep19332. [More Information]

Rispal D., Eltschinger S., Stahl M., Vaga S., Bodenmiller B., Abraham Y., Filipuzzi I., Movva N.R., Aebersold R., Helliwell S.B., Loewith R.  “Target of Rapamycin Complex 2 regulates actin polarization and endocytosis via multiple pathways”. JBC. (2015). In press. [More Information]

Gaubitz C., Oliveira T.M., Prouteau M., Leitner A., Karuppasamy M., Konstantinidou G., Rispal D., Eltschinger S., Robinson G.C., Thore S., Aebersold R., Schaffitzel C. and Loewith R. “Molecular basis of the rapamycin insensitivity of Target Of Rapamycin Complex 2”. Mol. Cell. 58(6):977-88. (Jun 18 2015). [More Information]

Da Silveira Dos Santos AX, Riezman I., Aguilera-Romero M.A., David F., Piccolis M., Loewith R., Schaad O., Riezman H., “Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis”. Mol Biol Cell. 25(20):3234-46. (Oct 15 2014). [More Information]