About Jérôme Waser
Jérôme Waser studied chemistry at the ETH Zurich. After a summer internship at Lonza AG
in Visp in 2000, he chose organic chemistry as specialization and obtained his Diploma
under the supervision of Prof. Erick M. Carreira and Dr. Christian Fischer in 2001. In
2002, he started his PhD studies at the ETH Zurich also under the supervision of Prof.
Erick M. Carreira. During his PhD, he worked on the development of new metal-catalyzed
amination reactions, which culminated in a new access to azides and hydrazines directly
from olefins. After obtaining his PhD in 2006, he joined the group of Prof. Barry M.
Trost at Stanford University as a postdoctoral fellow. While at Stanford, he worked on
the total synthesis of Pseudolaric Acid B, a diterpene natural product displaying
interesting antifungal, antifertility and antitumor activity.
At the EPFL, he is Head of the Laboratory of Catalysis and Organic Synthesis (LCSO). His
research is focused on the discovery of new catalytic reactions and their application to
the synthesis of bioactive compounds. The developed synthetic methods can then be used
for the diversity- or target- oriented synthesis of small molecules as valuable tools to
study biological processes or develop new drugs.
Read more about Jérôme Waser’s research on his lab website.
Contact
EPFL SB ISIC LCSO
BCH 4306 (Batochime UNIL)
Av. F.-A. Forel 2
1015 Lausanne, Switzerland
Phone: +41 (0)21 69 39388, +41 (0)21 69 39782
Email: [email protected]
Publications
Emmanuelle M. D. Allouche, Elija Grinhagena, Jerome Waser,
“Hypervalent Iodine-Mediated Late-Stage Peptide and Protein
Functionalization”, Angew. Chem. Int. Ed. 2022, 61,
e202112287. Open
access [More Information]
Voutyritsa, E.; Garreau, M.; Kokotou, M. G.; Triandafillidi, I.; Waser,
J.; Kokotos, C. G., “Photochemical Functionalization of
Heterocycles with EBX Reagents: C−H Alkynylation versus Deconstructive
Ring Cleavage”, Chem. Eur. J. 2020, 26 , 14453-14460.
Full access
[More Information]
Bumhee Lim, Yangyang Cheng, Takehiro Kato, Anh-Tuan Pham, Eliott Le Du,
Abhaya Kumar Mishra, Elija Grinhagena, Dimitri Moreau, Naomi Sakai,
Jerome Waser, Stefan Matile, “Inhibition of Thiol-Mediated Uptake
with Irreversible Covalent Inhibitors”, Helvetica Chimica
Acta, 104, e2100085, 2021. Open access. Dataset info.
[More Information]
Javier Ceballos, Elija Grinhagena, Gontran Sangouard, Christian Heinis,
Jerome Waser, “Cys–Cys and Cys–Lys Stapling of Unprotected
Peptides Enabled byHypervalent Iodine Reagents”, Ang. Chemie
int. ed., Volume 60, Issue 16, 9022-9031, 2021. [More
Information]
Eliott Le Du, Marion Garreau, Jérôme Waser, “Small peptide
diversification through photoredox-catalyzed oxidative C-terminal
modification”, Chem. Sci., 12, 2467-2473, 2021. Open access. Dataset info.
[More Information]
Stephanie G. E. Amos, Marion Garreau, Luca Buzzetti and Jerome Waser,
“Photocatalysis with organic dyes: facile access to reactive
intermediates for synthesis”, Beilstein J. Org. Chem. 16,
1163–1187, 2020. Open
access [More Information]
Marion Garreau, Franck Le Vaillant, Jerome Waser, “C-Terminal
Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative
Alkynylation”, Angew. Chem., 2019. [More
Information]
Romain Tessier, Javier Ceballos, Nora Guidotti, Raphael Simonet-Davin, Beat Fierz, Jérôme Waser, “Doubly Orthogonal Labeling
of Peptides and Proteins”, Chem, Volume 5, Issue
8, 2019, 1932-1934. / Dataset info -
Data set title: “Doubly Orthogonal Labeling of
Peptides and Proteins”. DPI: 10.5281/zenodo.3246280.
Responsible person: Beat Fierz. [More
Information]
Franck Le Vaillant, Marion Garreau, Stefano
Nicolai, Ganna Gryn’ova, Clemence Corminboeuf, Jerome Waser, “Fine-tuned organic photoredox
catalysts for fragmentation-alkynylation cascades of cyclic
oxime ethers”, Chem.
Sci., DOI: 10.1039/C8SC01818A, 2018.
[More Information]
Racine S., Hegedüs B., Scopelliti R., Waser J., “Divergent Reactivity of
Thioalkynes in Lewis Acid Catalyzed Annulations with Donor–Acceptor
Cyclopropanes”, Chem. Eur. J., 2016, 22, 11997.
[More Information]
Racine S., Hegedus B., Scopelliti R., Waser J. “Divergent Reactivity of
Thioalkynes in Lewis Acid-Catalyzed Annulations with Donor –Acceptor
Cyclopropanes”. Chem. Eur. J., 22, 34, 2016. [More
Information]
Racine S., Vuilleumier J., Waser, J., “Nucleoside analogues: synthesis
from strained rings”, Isr. J. Chem. (2016). doi: 10.1002/ijch.201500090.
[More Information]
Morelli P., Martin-Benlloch X., Tessier R., Waser J., Sakai N., Matile
S., “Ethynyl benziodoxolones: functional terminators for
cell-penetrating poly(disulfide)s”, Polym. Chem., (2016), 7, 3465-3470.
[More Information]
Abegg D., Frei R., Cerato L., Hari D.P., Wang C., Waser J., Adibekian A.
“Proteome-Wide Profiling of Targets of Cysteine-reactive Small Molecules
by using Ethynyl Benziodoxolone Reagents” Angew. Chem. 2015, 127,
11002-11007; Angew. Chem., Int. Ed., 54, 10852-10857, (2015).
[More Information]
Perrotta D., Racine S., Vuilleumier J., de Nanteuil F., Waser J.,
“[4+2]-Annulations of Aminocyclobutanes”, Org. Lett. (2015), 17,
1030-1033 [More Information]
