About Jérôme Waser
Jérôme Waser studied chemistry at the ETH Zurich. After a summer internship at Lonza AG in Visp in 2000, he chose organic chemistry as specialization and obtained his Diploma under the supervision of Prof. Erick M. Carreira and Dr. Christian Fischer in 2001. In 2002, he started his PhD studies at the ETH Zurich also under the supervision of Prof. Erick M. Carreira. During his PhD, he worked on the development of new metal-catalyzed amination reactions, which culminated in a new access to azides and hydrazines directly from olefins. After obtaining his PhD in 2006, he joined the group of Prof. Barry M. Trost at Stanford University as a postdoctoral fellow. While at Stanford, he worked on the total synthesis of Pseudolaric Acid B, a diterpene natural product displaying interesting antifungal, antifertility and antitumor activity.
At the EPFL, he is Head of the Laboratory of Catalysis and Organic Synthesis (LCSO). His research is focused on the discovery of new catalytic reactions and their application to the synthesis of bioactive compounds. The developed synthetic methods can then be used for the diversity- or target- oriented synthesis of small molecules as valuable tools to study biological processes or develop new drugs.
Read more about Jérôme Waser’s research on his lab website.
Contact
EPFL SB ISIC LCSO
BCH 4306 (Batochime UNIL)
Av. F.-A. Forel 2
1015 Lausanne, Switzerland
Phone: +41 (0)21 69 39388, +41 (0)21 69 39782
Email: jerome.waser@epfl.ch
Publications
Eliott Le Du, Marion Garreau, Jérôme Waser, “Small peptide diversification through photoredox-catalyzed oxidative C-terminal modification”, Chem. Sci., 2021, Advance Article. [More Information]
Stephanie G. E. Amos, Marion Garreau, Luca Buzzetti and Jerome Waser, “Photocatalysis with organic dyes: facile access to reactive intermediates for synthesis”, Beilstein J. Org. Chem. 16, 1163–1187, 2020. Open access [More Information]
Marion Garreau, Franck Le Vaillant, Jerome Waser, “C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation”, Angew. Chem., 2019. [More Information]
Romain Tessier, Javier Ceballos, Nora Guidotti, Raphael Simonet-Davin, Beat Fierz, Jérôme Waser, “Doubly Orthogonal Labeling of Peptides and Proteins”, Chem, Volume 5, Issue 8, 2019, 1932-1934. / Dataset info – Data set title: “Doubly Orthogonal Labeling of Peptides and Proteins”. DPI: 10.5281/zenodo.3246280. Responsible person: Beat Fierz. [More Information]
Franck Le Vaillant, Marion Garreau, Stefano Nicolai, Ganna Gryn’ova, Clemence Corminboeuf, Jerome Waser, “Fine-tuned organic photoredox catalysts for fragmentation-alkynylation cascades of cyclic oxime ethers”, Chem. Sci., DOI: 10.1039/C8SC01818A, 2018.
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Racine S., Hegedüs B., Scopelliti R., Waser J., “Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor–Acceptor Cyclopropanes”, Chem. Eur. J., 2016, 22, 11997. [More Information]
Racine S., Hegedus B., Scopelliti R., Waser J. “Divergent Reactivity of Thioalkynes in Lewis Acid-Catalyzed Annulations with Donor –Acceptor Cyclopropanes”. Chem. Eur. J., 22, 34, 2016. [More Information]
Racine S., Vuilleumier J., Waser, J., “Nucleoside analogues: synthesis from strained rings”, Isr. J. Chem. (2016). doi: 10.1002/ijch.201500090. [More Information]
Morelli P., Martin-Benlloch X., Tessier R., Waser J., Sakai N., Matile S., “Ethynyl benziodoxolones: functional terminators for cell-penetrating poly(disulfide)s”, Polym. Chem., (2016), 7, 3465-3470. [More Information]
Abegg D., Frei R., Cerato L., Hari D.P., Wang C., Waser J., Adibekian A. “Proteome-Wide Profiling of Targets of Cysteine-reactive Small Molecules by using Ethynyl Benziodoxolone Reagents” Angew. Chem. 2015, 127, 11002-11007; Angew. Chem., Int. Ed., 54, 10852-10857, (2015). [More Information]
Perrotta D., Racine S., Vuilleumier J., de Nanteuil F., Waser J., “[4+2]-Annulations of Aminocyclobutanes”, Org. Lett. (2015), 17, 1030-1033 [More Information]
Abegg D., Frei R., Cerato L., Hari D.P., Wang C., Waser J., Adibekian A., “ProteomeWide Profiling of Targets of Cysteine-reactive Small Molecules by using Ethynyl Benziodoxolone Reagents”, Angew. Chem. (2015), 127, 11002-11007; Angew. Chem. Int. Ed. (2015), 54, 10852-10857. [More Information]
