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Gisou van der Goot

Gisou van der Goot

Laboratory of Cell and Membrane Biology, EPFL

About Gisou van der Goot

Gisou van der Goot studied engineering at the Ecole Centrale de Paris, then did a PhD in Molecular Biophysics at the Nuclear Energy Research Center, Saclay, France, followed by a postdoc at the European Molecular Biology Laboratory (EMBL) in Heidelberg. She started her own group in 1994 in the department of Biochemistry, University of Geneva, became Associate professor at the Faculty of Medicine (Univ. Geneva) in 2001 and finally Full Professor at the EPFL in 2006, where she co-founded the Institute of Global Health. In 2014, she was appointed Dean of EPFL’s School of Life Sciences.

She is a professor at the Global Health Institute of EPFL. Her research interests are focused on protein folding, protein-membrane interactions and signaling which her lab investigates through the study of bacterial toxins and their receptors on target cells. She was also the coordinator of the LipidX consortium, sponsored by

Read more about Gisou van der Goot’s research on her lab website.


Station 19 – Office: AI 3148
1015 Lausanne, Switzerland
Phone: +41 (0)21 693 1791


Mesquita F.S., Abrami L., Sergeeva O., Turelli P., Qing E., Kunz B., Raclot C., Paz Montoya J., Abriata L.A., Gallagher T., Dal Peraro M., Trono D., D’Angelo G., van der Goot F.G., “S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity”, Dev. Cell., 2021 Oct 25; 56(20): 2790–2807.e8.  Open access [More Information]

Castanon I., Hannich J.T., Abrami L., Huber F., Dubois M., Müller M., van der Goot F., Gonzalez-Gaitan M., “Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish”, 11, Article number: 3317, 2020. Open access. Dataset info [More Information]

Laurence Abrami, Martina Audagnotto, Sylvia Ho, Maria Jose Marcaida, Francisco S. Mesquita, Muhammad U. Anwar, Patrick A. Sandoz, Giulia Fonti, Florence Pojer, Matteo Dal Peraro and F. Gisou van der Goot, “Molecular mode of action of an Acyl Protein thioesterase”, bioRxiv, 2020. [More Information]

Oksana A. Sergeeva and F. Gisou van der Goot, “Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes”, PNAS January 22, 2019 116 (4) 1279-1288. Open access [More Information]

Zaballa M.E. & van der Goot F.G., “The molecular era of protein S-acylation: spotlight on structure, mechanisms and dynamics”, Critical Reviews in Biochemistry and Molecular Biology, 53(4):420-451, 2018. [More Information]

Abrami, L., Dallavilla., T, Sandoz, P., Demir, M., Kunz, B., Savoglidis, G., Hatzimanikatis, V., van der Goot F.G., “Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade”, eLife. 15;6. pii: e27826, 2017. [More Information]