About Gisou van der Goot
Gisou van der Goot studied engineering at the Ecole Centrale de Paris, then did a PhD in
Molecular Biophysics at the Nuclear Energy Research Center, Saclay, France, followed by
a postdoc at the European Molecular Biology Laboratory (EMBL) in Heidelberg. She started
her own group in 1994 in the department of Biochemistry, University of Geneva, became
Associate professor at the Faculty of Medicine (Univ. Geneva) in 2001 and finally Full
Professor at the EPFL in 2006, where she co-founded the Institute of Global Health. In
2014, she was appointed Dean of EPFL’s School of Life Sciences.
She is a professor at the Global Health Institute of EPFL. Her research interests are
focused on protein folding, protein-membrane interactions and signaling which her lab
investigates through the study of bacterial toxins and their receptors on target cells.
She was also the coordinator of the LipidX consortium, sponsored by SystemsX.ch.
Read more about Gisou van der Goot’s research on her lab website.
Contact
EPFL SV GHI VDG
Station 19 - Office: AI 3148
1015 Lausanne, Switzerland
Phone: +41 (0)21 693 1791
Publications
Mesquita F.S., Abrami L., Sergeeva O., Turelli P., Qing E., Kunz B.,
Raclot C., Paz Montoya J., Abriata L.A., Gallagher T., Dal Peraro M.,
Trono D., D’Angelo G., van der Goot F.G., “S-acylation controls
SARS-CoV-2 membrane lipid organization and enhances infectivity”,
Dev. Cell., 2021 Oct 25; 56(20): 2790–2807.e8. Open
access [More
Information]
Abrami L, Audagnotto M, Ho S, Marcaida MJ, Mesquita FS, Anwar MU, Sandoz
PA, Fonti G, Pojer F, Dal Peraro M, van der Goot FG.,
“Palmitoylated acyl protein thioesterase APT2 deforms membranes to
extract substrate acyl chains”, Nat Chem Biol.
Apr;17(4):438-447, 2021. [More Information]
Castanon I., Hannich J.T., Abrami L., Huber F., Dubois M., Müller M., van
der Goot F., Gonzalez-Gaitan M., “Wnt-controlled sphingolipids
modulate Anthrax Toxin Receptor palmitoylation to regulate oriented
mitosis in zebrafish”, 11, Article number: 3317, 2020.
Open access.
Dataset
info [More Information]
Laurence Abrami, Martina Audagnotto, Sylvia Ho, Maria Jose Marcaida,
Francisco S. Mesquita, Muhammad U. Anwar, Patrick A. Sandoz, Giulia
Fonti, Florence Pojer, Matteo Dal Peraro and F. Gisou van der Goot,
“Molecular mode of action of an Acyl Protein thioesterase”,
bioRxiv, 2020. [More Information]
Oksana A. Sergeeva and F. Gisou van der Goot, “Anthrax toxin
requires ZDHHC5-mediated palmitoylation of its surface-processing host
enzymes”, PNAS January 22, 2019 116 (4) 1279-1288. Open
access [More Information]
Zaballa M.E. & van der Goot F.G., “The molecular era of protein
S-acylation: spotlight on structure, mechanisms and dynamics”,
Critical Reviews in Biochemistry and Molecular Biology,
53(4):420-451, 2018. [More Information]
Abrami, L., Dallavilla., T, Sandoz, P., Demir, M., Kunz, B., Savoglidis,
G., Hatzimanikatis, V., van der Goot F.G., “Identification and dynamics
of the human ZDHHC16-ZDHHC6 palmitoylation cascade”, eLife.
15;6. pii: e27826, 2017. [More Information]
Haag S.M., Gulen M.F., Reymond L., Gibelin A., Abrami L., Decout A.,
Heymann M., van der Goot F.G., Turcatti G., Behrendt R., Ablasser A.,
“Targeting STING with covalent small-molecule inhibitors”,
Nature volume 559, 269–273, 2018. [More
Information]
Blanc M., David F., Abrami L., Migliozzi D., Armand F., Bürgi J., Van der
Goot F.G. “SwissPalm: Protein Palmitoylation database”, F1000Res. (2015
Jul) 16;4:261. doi: 10.12688/f1000research.6464.1. eCollection.
[More Information]
Van der Goot F.G., and Gruenberg J. “Close encounter of the third
kind: the ER meets endosomes at fission sites”. Developmental
Cell. 31:673-674 (2014). [More Information]
Blaskovic S., Adibekian A., Blanc M., Van der Goot G.F.
“Mechanistic effects of protein palmitoylation and the cellular
consequences thereof”. Chem Phys Lipids. 180:44-52. (2014).
[More Information]
