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Gerardo Turcatti

Gerardo Turcatti


About Gerardo Turcatti

Gerardo Turcatti, M.E.R., directs the Biomolecular Screening Facility, a multidisciplinary laboratory created in 2006 at the EPFL, to perform medium and high throughput screening in life sciences-related projects at the EPF. The facility has the necessary infrastructure, multidisciplinary expertise and flexibility to perform large screening programs using small interfering RNAs (siRNAs) and chemical collections in the areas of chemical biology, systems biology and drug discovery.  Within the frame of the NCCR Chemical Biology, BSF developed the Academic Chemical Screening platform of Switzerland (ACCESS), so as to providethe scientific community with chemical diversity, screening facilities and know-how in chemical genetics. In addition, the BSF started its own applied research axes that are driven by innovation in thematic areas related to preclinical drug discovery and discovery of bioactive probes.

Read more about Gerardo Turcatti’s research on his lab website.


AAB 003 (Bâtiment AAB)
Station 15
1015 Lausanne, Switzerland
Phone : +41(0)21 693 96 66


Marchand, A.; Van Bree, J. W. M.; Taki, A. C.; Moyat, M.; Turcatti, G.; Chambon, M.; Smith, A. A. T.; Doolan, R.; Gasser, R. B.; Harris, N. L.; Bouchery, T., “Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway”, Pharmaceuticals 2022, 15 (6), 669. Open access [More Information]

Shrestha N., Gall F. M., Mathieu C., Hierweger M. M., Brügger M., Alves M. P., Vesin J., Banfi D., Kalbermatter D., Horvat B., Chambon M., Turcatti G., Fotiadis D., Riedl R., Plattet P., Cattaneo R., Griffin D. E., “Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier”, mBio 2021, 12 (6), e02621-21. Open access [More Information]

Luca Murer, Romain Volle, Vardan Andriasyan, Anthony Petkidis, Alfonso Gomez-Gonzalez, Liliane Yang, Nicole Meili, Maarit Suomalainen, Michael Bauer, Daniela Policarpo Sequeira, Dominik Olszewski, Fanny Georgi, Fabien Kuttler, Gerardo Turcatti, Urs F. Greber, “Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern”, Current Research in Virological Science, Volume 3, 2022. Open access [More Information]

Luca Murer, Romain Volle, Vardan Andriasyan, Nicole Meili, Liliane Yang, Daniela Sequeira, Afonso Gomez-Gonzalez, Anthony Petkidis, Dominik Olszewski, Michael Bauer, Maarit Suomalainen, Fabien Kuttler, Gerardo Turcatti, Urs F. Greber, “Arrayed multicycle drug screens identify broadly acting chemical inhibitors for repurposing against SARS-CoV-2”, bioRxiv 2021.03.30.437771. Open access [More Information]

Ganesh Kumar Mothukuri, Sangram S Kale, Carl Leonard Stenbratt, Alessandro Zorzi, Jonathan Vesin, Julien Bortoli Chapalay, Kaycie Deyle, Gerardo Turcatti, Laura Cendron, Alessandro Angelini and Christian Heinis, “Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries”, Chem. Sci., 11, 7858-7863, 2020. Open access [More Information]

Simon-Ulysse Vallet, Lykke Haastrup Hansen, Freja Cecillie Bistrup, Signe Aagaard Laursen, Julien Bortoli Chapalay, Marc Chambon, Gerardo Turcatti, Patrick H. Viollier, Clare L. Kirkpatrick, “Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics”, American Society for Microbiology, 2020. Open access [More Information]

Kale S.S., Bergeron-Brlek M., Wu Y., Kumar M.G., Pham M.V., Bortoli J., Vesin J., Kong X.D., Machado J.F., Deyle K., Gonschorek P., Turcatti G., Cendron L., Angelini A., Heinis C., “Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands”, Science Advances, 5, eaaw2851. Open access [More Information]

Scott C.C., Vossio S., Vacca F., Snijder B., Larios J., Schaad O., Guex N., Kuznetsov D., Martin O., Chambon M., Turcatti G., Pelkmans L., and Gruenberg J. “Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis”. EMBO reports. DOI 10.15252/embr.201540081, (2015). [More Information]