About Christian Heinis
Christian Heinis studied biochemistry at the Swiss Federal Institute of Technology in
Zurich (ETH). After a PhD in the research group of Prof. Dr. Dario Neri at ETH, he did
two post-docs, the first one with Prof. Dr. Kai Johnsson at the Ecole Polytechnique
Fédéral de Lausanne (EPFL) and the second one with Sir Gregory Winter at the Laboratory
of Molecular Biology (LMB) in Cambridge, UK. In 2008 he started as Assistant Professor
at EPFL (supported with an SNSF professorship) and was promoted in 2015 to Associate
Professor. He is co-Director of the NCCR Chemical Biology, member of the NCCR Steering
Committee and the NCCR Education Committee..
His research aims at developing therapeutics based on peptide macrocycles using novel
biological and chemical tools. An important activity of his laboratory is the generation
of antagonists based on bicyclic peptides by phage display. Christian is a scientific
co-founder of the start-up company Bicycle Therapeutics.
Read more about Christian Heinis’s research on his lab website.
Contact
Ecole polytechnique fédérale de Lausanne
Institut des sciences et ingénierie chimiques
EPFL SB ISIC LPPT
BCH 5305 (Bâtochime)
1015 Lausanne, Switzerland
Phone: +41 (0)21 693 93 50
Email: [email protected]
Publications
Sevan Habeshian, Ganesh A. Sable, Mischa Schüttel, Manuel L. Merz,
Christian Heinis, “Cyclative Release Strategy to Obtain Pure
Cyclic Peptides Directly from the Solid Phase”, ACS Chem. Biol. 2022,
17, 1. [More
Information]
Gontran Sangouard, Alessandro Zorzi, Yuteng Wu, Edouard Ehret, Mischa
Schüttel, Sangram Kale, Cristina Diaz Perlas, Jonathan Vesin, Julien
Bortoli Chapalay, Gerardo Turcatti, Christian Heinis,
“Picomole-scale synthesis and screening of macrocyclic compound
libraries by acoustic liquid transfer”, Angewandte Chemie Int.
Ed., 2021. [More Information]
Kong X.D., Heinis C., “Towards the Development of Orally Available
Peptide Therapeutics”, Chimia, 75(6), 514-517, 2021.
Open
access [More Information]
Javier Ceballos, Elija Grinhagena, Gontran Sangouard, Christian Heinis,
Jerome Waser, “Cys–Cys and Cys–Lys Stapling of Unprotected
Peptides Enabled byHypervalent Iodine Reagents”, Ang. Chemie
int. ed., Volume 60, Issue 16, 9022-9031, 2021. [More
Information]
Ganesh Kumar Mothukuri, Sangram S Kale, Carl Leonard Stenbratt,
Alessandro Zorzi, Jonathan Vesin, Julien Bortoli Chapalay, Kaycie Deyle,
Gerardo Turcatti, Laura Cendron, Alessandro Angelini and Christian
Heinis, “Macrocycle synthesis strategy based on step-wise
“adding and reacting” three components enables screening of
large combinatorial libraries”, Chem. Sci., 11,
7858-7863, 2020. Open
access [More Information]
Xu-Dong Kong, Jun Moriya, Vanessa Carle, Florence Pojer, Luciano A.
Abriata, Kaycie Deyle, Christian Heinis, “De novo development of
proteolytically resistant therapeutic peptides for oral
administration”, Nature Biomedical Engineering, 2020.
Dataset info
“Next generation sequencing data for phage
selection against FXIa“. [More
Information]
Khan Maola, Jonas Wilbs, Jeremy Touati, Michal Sabisz, Xu‐Dong Kong,
Alice Baumann, Kaycie Deyle, Christian Heinis, “Engineered peptide
macrocycles can inhibit matrix metalloproteinases with high
selectivity”, Ang. Chemie, vol. 58, issue 34, 2019. Free
access [More
Information]
Kale S.S., Bergeron-Brlek M., Wu Y., Kumar M.G., Pham M.V., Bortoli J.,
Vesin J., Kong X.D., Machado J.F., Deyle K., Gonschorek P., Turcatti G.,
Cendron L., Angelini A., Heinis C., “Thiol-to-amine cyclization reaction
enables screening of large libraries of macrocyclic compounds and the
generation of sub-kilodalton ligands”, Science Advances, 5,
eaaw2851. Open
access [More Information]
Sangram S. Kale, Camille Villequey, Xu-Dong Kong, Alessandro Zorzi,Kaycie
Deyle & Christian Heinis, “Cyclization of peptides with two
chemical bridges affords large scaffold diversities”, Nature Chemistry, 30 April 2018. DOI:
10.1038/s41557-018-0042-7. [More
Information]
Rentero Rebollo I., McCallin S., Bertoldo D., Entenza J., Moreillon P.
and Heinis C., “Development of potent and selective S. Aureus
sortase A inhibitors based on peptide macrocycles”, ACS Medicinal
Chemistry Letters, 7(6), 606-11, (2016). [More Information]
Diderich P., Bertoldo D., Dessen P., Khan M.M., Pizzitola I., Held W.,
Huelsken J. and Heinis C., “Phage selection of chemically
stabilized alpha-helical peptide ligands”, ACS Chemical Biology,
11(5), 1422-7, (2016). [More Information]
Baeriswyl V., Calzavarini S., Chen S., Zorzi A., Bologna L.,
Angelillo-Scherrer A., and Heinis C. “A synthetic factor XIIa
inhibitor blocks selectively intrinsic coagulation initiation”,
ACS Chemical Biology, (2015). [More Information]
Rentero Rebollo I., Sabisz M., Baeriswyl V. and Heinis C.,
“Identification of target-binding peptide motifs by
high-throughput sequencing of phage-selected peptides”, Nucleic
Acids Research, (2015). [More Information]
Urech-Varenne C., Radtke F., Heinis C., “Phage Selection of Bicyclic
Peptide Ligands of the Notch1 Receptor”, ChemMedChem, 10, 1754 – 1761,
2015. [More Information]
Chen S., Gopalakrishnan R., Schaer T., Marger F., Hovius R., Bertrand D.,
Pojer F. and Heinis C. “Dithiol amino acids can structurally shape
and enhance the ligand-binding properties of polypeptides”, Nature
Chemistry, 6, 1009-1016 , (2014). [More Information]
Pollaro L., Raghunathan S., Morales-Sanfrutos J., Angelini A., Kontos S.
and Heinis C. “Bicyclic peptides conjugated to an albumin-binding
tag diffuse efficiently into solid tumors”, Molecular Cancer
Therapeutics, 14, 151-61, (2014). [More Information]
