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Beat Fierz

Beat Fierz

Chemical Sciences and Engineering, EPFL

About Beat Fierz

Beat Fierz studied Molecular Biology at the Biozentrum of the University of Basel from 1998 – 2001. He then became interested in quantitative aspects of biology and obtained a Diploma in Biophysical Chemistry under the supervision of Prof. Thomas Kiefhaber in 2002. Then he performed his PhD studies (2002-2006) in Prof. Kiefhaber’s lab at the Biozentrum, where he investigated the dynamics of synthetic polypeptides and protein secondary structure elements using ultrafast time-resolved spectroscopy. In 2007 he joined the laboratory of Prof. Tom W Muir at the Rockefeller University, New York, and later Princeton University, New Jersey. There, he studied the folding behavior of chromatin fibers as well as the stability of nucleosome particles, depending on histone post-translational modifications. In 2012, he was appointed Tenure Track Assistant Professor for the newly created Chaire Fondation Sandoz en chimie biophysique des macromolécules.

He focuses on the study of the structure, dynamics and function of chromatin and related multi-protein complexes in vitro and in cells. These investigations require an interdisciplinary approach at the interface of chemistry, biology and biophysics.

Beat Fierz is a member of the NCCR steering committee.

Read more about Beat Fierz’s research on his lab website.


Ecole polytechnique fédérale de Lausanne
Institut des sciences et ingénierie chimiques
CH B3 485 (Bât. CH)
Station 6
1015 Lausanne, Switzerland
Phone: +41 (0)21 693 71 53


Pathare G., Decout A., Glück S., Cavadini S., Makasheva K., Hovius R., Kempf G., Weiss J., Guey B., Melenec P., Fierz B., Thomä N.H*., Ablasser A.*, “Structural mechanism of cGAS inhibition by the nucleosome”, Nature, 587, 668-672, 2020. [More Information]