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Aurélien Roux

Aurélien Roux

Biochemistry Department, University of Geneva

About Aurélien Roux

Aurélien Roux is an Associate Professor and Director of the department of Biochemistry, University of Geneva. His main interest is to study the role of lipid membrane mechanical properties in several cell processes, from endocytosis to cytokinesis. As a PhD student, he worked in collaboration with cell biologists (Bruno Goud’s lab, Curie Institute, Paris) and physicists (Patricia Bassereau’s lab, Curie Institute, Paris) in order to understand how membrane properties (e.g. bending rigidity, tension, and composition) facilitate or interfere with various stages of membrane traffic within cells. His continuing interest in membrane fission led him to pursue post-doctoral work in Pietro de Camilli’s laboratory. In order to study the mechanism of membrane tubule formation and fission by dynamin. From July 2007 to April 2010, as a Chargé de Recherche in the CNRS, France, he has been interested in how membrane properties affect the polymerization of dynamin onto a template.

His current research focuses is on the mechanical and dynamic properties of lipids and proteins involved in membrane traffic, so as to understand how proteins exploit the peculiar physical properties of lipid membranes in order to proceed with their function. Specifically, how do the essential physico-chemical abilities of membranes like deformation, fusion, fission, fluidity and permeability support cell functions involving membranes, like endocytosis, cell-division, cell migration and others.

Aurélien Roux is a member of the equal opportunity committee.

Read more about Aurélien Roux’s research on his lab website.

Contact

University of Geneva, Science II
Biochemistry Department
30, quai Ernest Ansermet
1211 Geneva 4, Switzerland
Phone: +41 (0)22 379 35 32
Email: aurelien.roux@unige.ch

Publications

Antoine Goujon, Adai Colom, Karolína Strakova, Vincent Mercier, Dora Mahecic, Suliana Manley, Naomi Sakai, Aurélien Roux, and Stefan Matile, “Mechanosensitive Fluorescent Probes To Image Membrane Tensionin Mitochondria, Endoplasmic Reticulum, and Lysosomes“, JACS, doi: 10.1021/jacs.8b13189, 2019. [More Information]

Radu Tanasescu,  Ute Mettal, Adai Colom, Aurélien Roux and Andreas Zumbuehl, “Facile and rapid Formation of Giant Vesicles from Glass Beads”, Polymers, 10(1), 54; doi:10.3390/polym10010054, 2018. [More Information]

Mierzwa BE, Chiaruttini N, Redondo-Morata L, von Filseck JM, König J, Larios J, Poser I, Müller-Reichert T, Scheuring S, Roux A, Gerlich DW, “Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis”, Nat Cell Biol. 2017 Jul;19(7):787-798.

Verolet Q., Dal Molin M., Colom A., Roux A., Guénée L., Sakai N., Matile S., “Twisted Push-Pull Probes with Turn-On Sulfide Donors”, Helv. Chim. Acta, 100, e1600328, 2017. [More Information]

Mierzwa B.*, Chiaruttini N.*, Redondo-Morata L.*, Moser von Filseck J., Koenig J., Larios J., Poser I., Mueller-Reichert T., Scheuring S., Roux A.*, Gerlich D.*, “Dynamic instability in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis”, Nature Cell Biology, accepted. (*co-first or co-last authors)

Colom A., Redondo-Morena L., Chiaruttini N., Roux A.*, Scheuring S.*, “Dynamic remodeling of the dynamin helix during membrane constriction”, Proceedings the National Academy of Sciences USA, online publication May 2017 (*co-last authors). [More Information]

Alessandri K., Feyeux M., Gurchenkov B., Delgado C., Trushko A., Krause K. H., Vignjević D., Nassoy P., Roux A., “A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC)”, Lab Chip, (2016),16, 1593-1604. [More Information]

Saleem M., Morlot S., Hohendahl A., Manzi J., Lenz M., Roux A. “A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats”. Nat Commun., Feb 19;6:6249. doi: 10.1038/ncomms7249, (2015). [More Information]

Chuard N., Gasparini G., Roux A., Sakai N., Matile S., “Cell-Penetrating Poly(disulfide)s: The Dependence of Activity, Depolymerization Kinetics and Intracellular Localization on Their Length”, Org. Biomol. Chem., 13, 64-67, (2015). (invited contribution to 2 special issues). [More Information]

Dal Molin M., Verolet Q., Colom A., Letrun R., Derivery E., Gonzalez-Gaitan M., Vauthey E., Roux A., Sakai N., Matile S. “Fluorescent Flippers for Mechanosensitive Membrane Probes”, J. Am. Chem. Soc., 137, 568-571, (2015). [More Information]