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Double-bridged peptides bind any disease target

NCCR scientists have developed a new type of “double-bridged peptide” that can be tailored to bind tightly to disease targets of interest. The work is published in Nature Chemistry.

A new way of fighting bacteria?

Microbiologists at the UNIGE, studied the toxin-antitoxin system HigBA, which can be found in many pathogenic and non-pathogenic bacteria, and found a novel regulatory mechanism with potential implications on how to fight bacterial infection.

New light on anti-sphingolipid targeting cancer therapy

NCCR researchers and other external labs identify the lysosomal transmembrane protein, LAPTM4B, as a specific ceramide binding protein and an alternative regulator of ceramide clearance from the late endosomes independently of the known ceramidase-dependent catabolism.

What exactly is Chemical Biology?

For its 10th anniversary, Nature Chemical Biology asked the question: “define chemical biology ?” to a panel of scientists.

EPFL scientists have developed a new amino acid

The team of Christian Heinis at EPFL has developed a synthetic amino acid whose unique structure can considerably increase the effectiveness of therapeutic peptides and proteins.