The Hoogendoorn lab
Sascha Hoogendoorn is a newly appointed tenure-track assistant professor in the department of Organic Chemistry and the NCCR Chemical Biology at the University of Geneva. She received her PhD in Organic Chemistry from the group of professor Herman Overkleeft at the University of Leiden, the Netherlands in 2013. In her PhD work, she used synthetic chemistry to develop receptor-targeting small molecules to accomplish selective cellular entry. She then moved to Stanford University where she worked in the group of Professor James Chen as a postdoctoral scholar, and developed a novel CRISPR/Cas9-based screening methodology to study ciliary Hedgehog signalling.
In her lab she uses an interdisciplinary approach to study and perturb cellular signalling, with a particular interest in the primary cilium and the Hedgehog signalling pathway. Her research combines organic chemistry with cell biology and CRISPR/Cas9-based gene editing to develop molecules that enable further dissection and manipulation of ciliary signalling.
The ERC Starting Grants 2020
The funding, worth in total €677 million, will help these early-career scientists and scholars to build their own teams and conduct pioneering research across all disciplines. The grantees are a diverse group with 40 different nationalities. Amongst the winners, 20 researchers are moving to Europe from further afield thanks to the funding. The new grantees will be based in 25 countries across Europe, with Germany (88 grants), the UK (62), the Netherlands (42) and France (38) as top locations. Some 13% of applications were selected for funding in this round. These Starting Grants will create an estimated 2,500 jobs for postdoctoral fellows, PhD students and other staff at the host institutions.