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Multilayered omics highlight adipose progenitor cell heterogeneity

What is molecular basis of the cellular heterogeneity harboured by adipose stroma cells that differentially impact tissue plasticity ? The NCCR Chemical Biology is proud to announce a new publication in Cell Metabolism which provides unprecedented insights thanks to the multilayered ‘omics techniques developed at the new Proteomics platform at UNIGE, under the supervision of Dr Yibo Wu.

Highlights from the publication

  • Integrated multilayer omics reveal molecular heterogeneity of adipose progenitors
  • Proteomic analysis highlights metabolic heterogeneity of adipose progenitors
  • PPARγ phosphorylation underlies sex differences in iWAT APC differentiation
  • Glutathione metabolism and AhR signaling regulate progenitor cell fate and function


Adipose tissue harbors functionally distinct progenitor cell subpopulations. The paper utilizes multilayered omics to dissect adipose progenitor cell heterogeneity in three dimensions: progenitor subpopulation, sex, and anatomical localization. State-of-the-art mass spectrometry methods are applied to acquire functional analysis underlying molecular signatures defining sex differences in preadipocyte activation and identify regulatory pathways controlling the adipogenic and pro-inflammatory properties of distinct progenitor subpopulations. This multilayered omics analysis is  freely accessible at   highlighting the benefit of complementary proteomics to support findings from scRNA-seq studies.


Bo Shan, Clive S. Barker, Mengle Shao, Qianbin Zhang, Rana K. Gupta & Yibo Wu, Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity, Cell Metabolism, 34, 1-17, 2022