Gonçalo Bernardes, Professor of Chemical Biology at the University of Cambridge (UK), focuses on the use of chemistry principles to tackle challenging biological problems for understanding and fight cancer. He will give the next NCCR online talk entitled “Translational chemical biology” on November 29, 2021.
About the talk: Translational chemical biology
Gonçalo Bernardes’ research uses chemistry principles to address questions of importance in life sciences and molecular medicine. His lecture will cover recent examples of emerging areas in his group in:
- Methods developed for site-selective chemical modification of proteins at cysteine, disulfide, lysine and serine and their use to build stable and functional protein conjugates for in vivo applications;
- Bioorthogonal cleavage reactions for targeted drug activation in cells;
- Click-degraders, small molecules that can be covalently attached to RNA species through click-chemistry and can degrade them, that are akin to ribonucleases. Using click-degraders we developed meCLICK-Seq, a powerful method for the study of diverse aspects of cellular RNA methylation.
About the speaker
Dr. Bernardes is Professor of Chemical Biology at the Yusuf Hamied Department of Chemistry, University of Cambridge. He is also a Group Leader at iMM Lisbon. His research group interests focus on the use of chemistry principles to tackle challenging biological problems for understanding and fight cancer. Gonçalo is the recipient of two European Research Council grants; a starting grant and a proof-of-concept grant, and was awarded the Harrison–Meldola Memorial Prize in 2016 and the MedChemComm Emerging Investigator Lectureship in 2018, both from the Royal Society of Chemistry, and the 2020 International Chemical Biology Society Award 2020. After completing his D.Phil. in 2008 at the University of Oxford, U.K. under the guidance of Prof. Ben Davis, Gonçalo undertook postdoctoral work at the Max-Planck Institute of Colloids and Interfaces, Germany with Prof. Peter Seeberger, and the ETH Zürich, Switzerland with Prof. Dario Neri, and worked as a Group Leader at Alfama Lda in Portugal. He is also a co-founder of Targ.Tex, a company that is developing a highly-targeted therapy for the treatment of glioblastoma multiforme.
Date: November 29, 2021
Duration: approximately 60’ (talk and Q&A)
Place: online, via Zoom (link will be sent to registered participants, a few days before the event)
Registration is now closed.