Yimon Aye’s research focuses on electrophilic signalling mechanisms which affect proteins function and the control of genome replication and allow the modulation of various biological processes, including cell ageing, cell decay, immune reactions and the protection of genetic material.
Beat Fierz focuses on the study of the structure, dynamics and function of chromatin and related multi-protein complexes in vitro and in cells. These investigations require an interdisciplinary approach at the interface of chemistry, biology and biophysics.
The ultimate goal of Christian Heinis lab is the development of therapeutics by developing peptide macrocycles for potential therapeutic application using phase based strategy and biological and chemical tools. His lab currently develops potent antagonists to a range of disease targets, following medical indications in which bicyclic peptides promise advantages over small molecules and monoclonal antibodies.
Robbie Loewith is Full Professor and Director of the Department of Molecular Biology. With particular focus on the Target Of Rapamycin kinases, his group uses chemical genetic approaches in yeast to dissect complex signalling pathways conserved in all eukaryotes.
Suliana Manley lab uses super-resolution fluorescence imaging techniques combined with live cell imaging and single molecule tracking to determine how the dynamics of protein assembly are coordinated. Her research interests include super-resolution fluorescence microscopy, high-density single molecule particle tracking, advanced fluorescence imaging, cellular imaging of protein and lipid transport and assembly.
Howard Riezman and his group are interested in the biogenesis, trafficking, properties, and physiological roles of biological membranes, with a focus on membrane lipids. Since 2010, he has been awarded the directorship of the NCCR Chemical Biology.
Nicolas Winssinger lab aims to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology. The group is particularly interested in the use of small molecules to probe dynamic processes in biological systems. The lab develops microarray-based tools to measure enzymatic activity on a proteomic scale, synthesise libraries of inhibitors and is also interested in imaging technologies to visualize biological events.