Andrea Ablasser’s research aims to understand how the cells of our immune system detect the presence of pathogens and to dissect the fundamental mechanisms that provide host defense.
The Aumeier lab explores the biochemistry and biophysics of the cytoskeleton. Her research addresses questions around how the cytoskeleton is organised and regulated in space and time, resulting in functional architecture.
Yimon Aye’s research focuses on electrophilic signalling mechanisms which affect proteins function and the control of genome replication and allow the modulation of various biological processes, including cell ageing, cell decay, immune reactions and the protection of genetic material.
Bruno Correia lab is driven by the passion of expanding nature’s repertoire by designing novel functional proteins to be used for practical purposes such as therapeutics, vaccines, biosensors and others. An innovative research from a new field called immunoengineering.
Lyndon Emsley’s main research field is solid-state NMR spectroscopy, specifically the development of new spectroscopic methods for the determination the atomic-level structure, the dynamics and the reactivity of a wide range of materials and molecular systems, that have been inaccessible with other analytical methods.
Beat Fierz focuses on the study of the structure, dynamics and function of chromatin and related multi-protein complexes in vitro and in cells. These investigations require an interdisciplinary approach at the interface of chemistry, biology and biophysics.
Pioneering in the development of novel (bio)chemical methods to map cellular protein-lipid interaction networks, the Gavin group has a strong research interest in the study of lipid metabolism and the regulation of cellular membranes homeostasis, with a special focus on the machinery involved in the creation and maintenance of lipid gradients in eukaryotic cells, and the study of mechanisms by which lipid signatures are sensed and “read” by effector proteins.
His main research interests lie in understanding fundamental cell division processes, notably in the context of a developing organism and with a focus on the mechanisms governing centriole biogenesis and centrosome duplication as well as asymmetric cell division, a crucial phenomena for generating cellular diversity during development and in stem cell lineages.
Gonzalez-Gaitan main research interest is the biophysics and cell biology of endocytic trafficking during morphogenetic signalling and asymmetric cell division, to understand how cells talk to each other during development in physical and molecular terms and how the shape and final size of a tissue is achieved during embryogenesis.
Gotta lab focuses on cell division processes in C. elegans embryo and in human cells, with a focus on asymmetric cell division, regulation of cell division timing and spindle assembly and orientation.
The ultimate goal of Christian Heinis lab is the development of therapeutics by developing peptide macrocycles for potential therapeutic application using phase based strategy and biological and chemical tools. His lab currently develops potent antagonists to a range of disease targets, following medical indications in which bicyclic peptides promise advantages over small molecules and monoclonal antibodies.
Sascha Hoogendoorn lab aims to study and perturb cellular signalling, with a particular interest in the primary cilium and the Hedgehog signalling pathway. Her research combines organic chemistry with cell biology and CRISPR/Cas9-based gene editing to develop molecules that enable further dissection and manipulation of ciliary signalling.
Marko Kaksonen is a professor in the Department of Biochemistry at the University of Geneva. His lab studies the molecular mechanisms of clathrin-mediated endocytosis.
Karsten Kruse lab studies the formation of spatial and temporal structures in individual biological cells and cell assemblies such as the cytoskeleton of eucaryotic cells and the Min-system in Escherichia coli, by using use methods from non-equilibrium statistical mechanics and non-linear dynamics.
Robbie Loewith is Full Professor and Director of the Department of Molecular Biology. With particular focus on the Target Of Rapamycin kinases, his group uses chemical genetic approaches in yeast to dissect complex signalling pathways conserved in all eukaryotes.
Suliana Manley lab uses super-resolution fluorescence imaging techniques combined with live cell imaging and single molecule tracking to determine how the dynamics of protein assembly are coordinated. Her research interests include super-resolution fluorescence microscopy, high-density single molecule particle tracking, advanced fluorescence imaging, cellular imaging of protein and lipid transport and assembly.
Stefan Matile research focuses at the interface of synthetic organic, biological and supramolecular materials chemistry with emphasis on the creation of functional biosupramolecular systems for broad applications such as organic solar cells, biosensors and the many ways to move across a bilayer membrane. He is an ERC Advanced Investigator, a project leader of the NCCR Chemical Biology as well as President of the School of Chemistry and Biochemistry at the UNIGE.
Howard Riezman and his group are interested in the biogenesis, trafficking, properties, and physiological roles of biological membranes, with a focus on membrane lipids. Since 2010, he has been awarded the directorship of the NCCR Chemical Biology.
Pablo Rivera-Fuentes is tenure-track assistant professor of chemical biology at EPFL. He leads the laboratory of chemical and biological probes.
With expertise in cell biology and biophysics, Aurélien Roux main research interest is to study the role of lipid membrane mechanical properties in several cell processes. His long-term goal is to understand how protein and lipid assemblies coordinate to perform cell functions involving membranes: endocytosis, cell division, cell migration and others.
Under the direction of Gearardo Turcatti, the Academic Chemical Screening platform of Switzerland (ACCESS) provides the scientific community with chemical diversity, screening facilities, medicinal chemistry and know-how in chemical genetics.
Gisou van der Goot research interests are focused on protein folding, protein-membrane interactions and signaling which her lab investigates through the study of bacterial toxins such as Anthrax toxin and their receptors on target cells. The role of palmitoylation in ER function and the mechanisms behind the compartimentalization of mamalian cells and cell membranes are other topics of interest.
The principal focus of the research conducted by the Waser group is the development and application of new catalytic methods for the synthesis of bioactive compounds. His lab harnesses the power of modern catalysis to promote C-C or C-X bond formation, allowing for a rapid and efficient enhancement in molecular complexity.
Nicolas Winssinger lab aims to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology. The group is particularly interested in the use of small molecules to probe dynamic processes in biological systems. The lab develops microarray-based tools to measure enzymatic activity on a proteomic scale, synthesise libraries of inhibitors and is also interested in imaging technologies to visualize biological events.